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The efforts to reach compromise between the North and the South failed because events kept happening to reopen the problems and bring them to people's attention again. For example, after the Missouri Compromise had things settled, the war with Mexico occurred and the problems started again. After the Compromise of 1850 had things settled, the Kansas-Nebraska Act happened and there was conflict yet again. As this happened more and more, the two sides came to hate each other too much to successfully compromise. Without these events that reopened the disputes, the compromises might have stuck and the war might not have happened.
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