What is the significance of Ostend Manifesto?
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The Ostend Manifesto was yet another thing that helped to push the North and the South apart in the time before the Civil War. In this case, it made the North more suspicious of the South's desire to expand slavery. (Incidentally, it might also have helped to lead to the Spanish-American War some 40 years later.)
The Ostend Manifesto stated that the US should take Cuba away from Spain. This was controversial in the US at the time (1854) because it was clear that Cuba, if taken by the US, would become a slave territory. This made the North feel as if the South was going to try to push the US into war for the purpose of expanding slave territory.
This perception made the North more angry at the South and the North's reaction annoyed the South. This pushed the two sections farther apart.
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