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What are the physical factors in the control of appetite?

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anat-n-phys | Honors

Posted October 29, 2013 at 12:22 AM via iOS

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What are the physical factors in the control of appetite?

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K.P.L. Hardison | College Teacher | eNotes Employee

Posted October 29, 2013 at 3:42 PM (Answer #1)

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Recent studies have shown a positive correlation between energy expenditure (EE), energy intake (EI) and energy balance (EB). R. James Stubbs, et al, have shown in a 2004 study published in American Society for Clinical Nutrition that a sedentary lifestyle does not lead to reduction in food and drink consumption, in EI, and results in a positive increase of stored calories, an increase EB, that results in increased weight. Katarina T. Borer, Ph.D., has identified that the human appetite controllers ghrelin and leptin, reportedly material in appetite control and/or suppression, respond to energy availability in terms of energy intake minus energy expenditure equalling available energy balance: EI - EE = EB --> effectiveness in operation of ghrelin and leptin. Imbalances (nonhomeostatic characteristics) relevant to activity levels fail to inhibit the homeostatic function of ghrelin and leptin in the brain's homeostatic control system that spans from the "hypothalamus to the caudal medulla" (H. Berthoud in Obesity 2006).

Nonhomeostatic characteristics of appetite and spontaneous activity stem from inhibition by leptin and ghrelin of brain reward circuit that is responsive to energy deficit. (Katarina T. Borer, Ph.D.)

Thus, according to recent studies in the wake of the present obesity epidemic, the physical factors of appetite control are, on the one hand, the homeostatic factors in the brain reward circuit of ghrelin and leptin and, on the other hand, energy expenditure (EE), energy intake (EI) and the resultant energy balance (EB), which increases as weight gain when EE decreases because EI remains unchanged.

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