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what is the mechanism of phenolic to inhibiting Candida albicans.

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sucijp | Student, Undergraduate | (Level 1) eNoter

Posted April 27, 2013 at 7:10 AM via web

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what is the mechanism of phenolic to inhibiting Candida albicans.

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jerichorayel | College Teacher | (Level 1) Senior Educator

Posted June 30, 2013 at 3:55 PM (Answer #1)

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Candida albicans is a fungus that is considered a diploid fungus which can affect humans through infections of organ systems. It is usually present in our gut but can be detrimental one the population increases (overgrowth). Now there are certain drugs in inhibiting the microorganisms in the body. These are Amphotericin for systemic infections, fluconazole for oral infections and azole for vaginal infections. 

Now there are researches on using phenolic substances in order to inhibit the growth of the fungi. One method is to inhibit the proteasome mechanisms that lead to the production of necessary protein for metabolism. When the Candida albicans cannot anymore produce proteins, it will stop proliferating and eventually dies. 

Another mechanism is the inhibition of biofilm formation of the Candida albicans. Once this biofilm is inhibited, the fungi cells will lose their connection to each other and to the surface which apparently can cause cell death.

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