What is gastric inhibitory polypeptide?
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It is a well characterized product of the small intestine, inhibiting both gastric mobility and gastric secretion. It has 43 amino acids, the sequence resembling with secretin and glucagon. Fifteen of the first 26 amino acids at the NH2-terminal end are in the same position as in porcine glucagon, while 9 of the first 26 amino acids are in the same position as in secretin. It has been suggested that it is identical with enterogastrone. Whether enterogastrone is indeed gastric inhibitory polypeptide is a little uncertain since the chemical characterization of the former is not complete, while the normal physiological stimulus for the release of the latter is not known.
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