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Since witches were indicative of evil and the supernatural in Shakespeare's day, having them introduce the first scene of the play starts the play with a sense of foreboding that something sinister and/or evil will occur. They agree to meet again on the heath when the battle is over. They expressly note that they will meet with Macbeth. Given that the witches represent evil, their upcoming meeting with Macbeth suggests that the supernatural world and the world of humans (Macbeth) will interact. Particularly, the witches will have some impact on Macbeth himself. The final lines blatantly indicate that bad things will happen.
Fair is foul, and foul is fair.
Hover through the fog and filthy air. (I.i.11-12)
In the next scene, we learn that Macbeth has fought bravely, a loyal servant to the king. At that point, Macbeth is described in good terms. But as the witches indicated that they will meet with Macbeth (in Scene Three), and as they indicated that what was good will become evil ("Fair is foul"), they allude, at least to the potential, that their upcoming meeting with Macbeth will have to do with a transition from good ("fair") to evil ("foul").
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