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What is the diference between endogenous insulin and exogenous insulin?

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coralie | Student, Undergraduate | eNotes Newbie

Posted February 23, 2010 at 1:52 PM via web

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What is the diference between endogenous insulin and exogenous insulin?

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krishna-agrawala | College Teacher | Valedictorian

Posted February 23, 2010 at 2:13 PM (Answer #1)

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Insulin is a polypeptide hormone produced by body that regulate the metabolism of carbohydrates and fat in the body.This insulin is produced in the human body by the pancreas.The insulin produced within human body is called endogenous insulin.

Patients suffering from the are treated by doses of insulin produced by sources external to the body of the patient and administered in addition to the endogenous insulin. This type of insulin produced by sources other than human body is called exogenous insulin.

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giorgiana1976 | College Teacher | Valedictorian

Posted February 23, 2010 at 7:39 PM (Answer #2)

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Insulin is a protein secreted by the pancreas, which acts on liver to stimulate the production of glycogen from glucose and to stop the processing of non-carbohydrates into glucose. Insulin also helps to spread glucose faster to insulin receptor cells, that including muscle tissues. Insulin has also an anabolic effect on bones, increasing their density.

Endogenous insulin (that which is found naturally in the body) acts on the principle of feedback.If glucose levels rise when eating something sweet, insulin secretion is increasing, too. When glucose is low, insulin is also low. Simply adding of liquid glucose in a bowl of liquid amino acids, increases with 50% their absorption.

Exogenous insulin (one that is found in vials) is used in case of diabetes, so that the misuse of insulin,it can turn someone into a  diabetic patient.

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dolphin1978 | College Teacher | eNotes Newbie

Posted February 23, 2010 at 3:23 PM (Answer #3)

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the human body has  agreat organ named the pancreas.

this pancreas has an area named  "Beta langerhans " responsible  for releasing a hormone named insulin. this insulin is needed for glucose(blood sugar from food intake) to enter the cells of the body to be used as fuel. without insulin the sugar will stay in the blood and will not be able to enter cells.

any thing produced inside the body is termed endogenous; hence this insulin is termed endogenous insulin.

people of diabetes mellitus ( a condition in which a person has a high blood sugar (glucose) level as a result of the body either not producing enough insulin type I , or because body cells do not properly respond to the insulin that is produced type II),these people of type I diabetes mellitus do not produce enough insulin, this is why they need an exogenous insulin (produced outside their bodies).

exogenous insulin could be obtained from beef (bovine insulin), pork (porcine insulin) which is the closest to human insulin , and recombinant (human) sources.

note that Insulin is administered by injection via the subcutaneous (under the skin) route.

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jbarnum11 | College Teacher | eNoter

Posted May 15, 2014 at 10:10 AM (Answer #4)

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Endogenous insulin is the insulin your pancreas makes which means it is coming from your body. Exogenous would be like giving someone insulin-a type I diabetic who no longer makes insulin would need exogenous insulin to keep blood sugars under control. Now, Type I and Type II are treated very differently and should be. Treatment of Type II should always be holding off on medications or insulin for as long as possible because research has shown that by taking over the job of endogenous insulin, you are actually speeding up the process of the need for exogenous insulin because your bodies metabolic pathways are activated at a different rate and learn to be utilized faster by bypassing the normal route as if someone did not have diabetes. It is always exercise and diet control first, then possibly mediations but with continued diet and exercise. Also, keeping medications at the lowest doses possible. Keeping in mind, stress, hormones, thyroid, illness, etc can all raise blood glucose and the Hemoglobin A1c is not able to be used to decipher is someone is a diabetic. The A1c looks at your sugar levels over 3-4 months. The best way to keep control of your sugars is carb counting, not fun and time consuming but worth it in the long run.

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