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Look in the first part of Chapter Five
Lennie kills the puppy in chapter 5. This chapter, as well as the other four, foreshadow the death of Curley's wife.
As far as the setting goes, the opening chapter gives a great description of the landscape. The reader also learns that George and Lennie are in Salinas, California, and they are going to the Hooper Ranch to work.
in chapter 5
Lennie killed the puppy in Chapter 5 of Of Mice and Men.
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