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What is the antidote of choice for anticoagulant rodenticide toxicities?

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greynose | Student, Undergraduate | (Level 2) Honors

Posted August 14, 2011 at 9:45 PM via web

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What is the antidote of choice for anticoagulant rodenticide toxicities?

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justaguide | College Teacher | (Level 2) Distinguished Educator

Posted August 14, 2011 at 11:13 PM (Answer #1)

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Anticoagulant Rodenticides which include Warfarin and Congeners are used to eliminate rodents. These chemicals work by disrupting the activity of vitamin K. This vitamin is essential for the formation of proteins that help in coagulation process of converting prothrombin into thrombin. As a result even a tiny rupture in the skin can lead to death due to loss of blood.

In case of poisoning by these rodenticides, the treatment is giving vitamin K1 subcutaneously. It is essential that this be done with the smallest rupture in the skin and at several places around the body so that the vitamin K1 can be absorbed at a fast rate.

 

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