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is tuberculosis disease part of epigenetics?

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lilly11 | Student, Grade 9 | eNotes Newbie

Posted January 18, 2011 at 9:38 AM via web

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is tuberculosis disease part of epigenetics?

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claramolee | eNoter

Posted January 23, 2011 at 5:01 PM (Answer #1)

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epigenetics (appearance) or is the study of inherited changes in phenotypegene expression caused by mechanisms other than changes in the underlying DNA sequence, hence the name epi- (Greek: επί- over, above) -genetics. These changes may remain through cell divisions for the remainder of the cell's life and may also last for multiple generations. However, there is no change in the underlying DNA sequence of the organism instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently.

The best example of epigenetic changes in eukaryotic biology is the process of cellular differentiation. During morphogenesis, totipotent stem cells become the various pluripotent cell lines of the embryo which in turn become fully differentiated cells. In other words, a single fertilized egg cell – the zygote – changes into the many cell types including neurons, muscle cells, epithelium, blood vessels etc. as it continues to divide. It does so by activating some genes while inhibiting others.

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