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Macbeth certainly does feel paranoia and guilt after Duncan's murder. However, as the play progresses, he doesn't hesitate to murder again to achieve his goal of beoming king. After he orders Banquo and Fleance's murder (he perceives them as threats to his goal), Banquo is killed but Fleance gets away. He sees Banquo's ghost at a dinner in his home, proving not only his paranoia but his progressive loss of sanity. However, he is angry with the murderers for allowing Fleance to get away and expresses how this loose end throws a monkey wrench in his plans. Finally, his relationship with Lady Macbeth, formally very strong and based on mutual support, changes dramatically because of his tragic flaw of thirsting for power. He refuses to share the additional murders he has planned, causing a major breakdown in their relationship.
When Macbeth returns after the murder of Duncan he is distraught and regrets the murder he has committed. Macbeth feels so guilty for the act that his mind projects voices that condemn him. He will no longer have the piece of mind that he had before the murder.
after the murder macbeth changes. in act 2 scene 2. he is very fearful and hears voices. also in this scene macbeth says "i could not say 'amen'" this shows he knows what he done was wrong. so he may have tried to make up for his wrong doing.
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