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From the article below, what is the impact...

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From the article below, what is the impact of depression?

http://focus.psychiatryonline.org/article.aspx?articleID=53128

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In this section, the authors describe a "weak overall connection between childhood negative life events and the development of depressive symptoms." But this connection is strongest in individuals who carry certain genetic traits, meaning that some people were genetically predisposed not to respond as well to negative life events. People who carried a certain genotype, the researchers observe, were more likely to experience depression in the aftermath of negative childhood events. But the association works the other way as well. In many cases, genetic variance could lead to a moderation of these effects. It is also the case that people with certain genetic patterns respond better to "high maternal nurturance," and other factors. 

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