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brandih | eNotes Employee

Posted March 23, 2011 at 1:23 PM via web

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- C - G- A- A- G- G- T- C- A- T- G- A - T - C - G- C - T- T- T- C- C- A- G-T- A- C- T- A- G

Does the deletion in the DNA molecule change the resulting protein? If so, in what way? One codon (UGA) in the altered mRNA does not specify an amino acid. Codons of this sort specify the ends of protein molecules

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trophyhunter1 | College Teacher | (Level 3) Senior Educator

Posted February 20, 2012 at 12:50 AM (Answer #1)

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In the sequence above, if the DNA molecule has a deletion, the UGA or stop codon, will occur in the mRNA complementary to the ACT triplet in the DNA, just before the end of the DNA template, but, not at the end. This stop codon will cause the ribosome to cease adding any further amino acids to the polypeptide chain. It will cause the protein to be slightly shorter than normal. If this is the case, when the protein detaches from the ribsome, and goes on to fold into a three dimensional shape, it may not be functional or fully functional because it might have a distorted shape. This can lead to a disorder or disease in a person when a necessary protein is not functional.

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