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1-What is the probabilty that Asha  will have a child with Niemann pick disease type...

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adilyas | eNoter

Posted May 9, 2013 at 9:20 PM via web

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1-What is the probabilty that Asha  will have a child with Niemann pick disease type A.

If Asha  is a healthy woman in her forties, does not have niemann pick disease type A , but she is carrier.

2-What is the probality that Amit will have a child with Niemann pick disease type A.

If Amit is a healthy man in his forties . his family history shows no Niemann -pick type A . thus he is not a carrier .

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orchid101 | College Teacher | (Level 1) Associate Educator

Posted May 10, 2013 at 1:16 PM (Answer #1)

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 If Asha is a carrier of the allele of niemann-pick disease type A, there is a 25% chance with each pregnancy for an affected child. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. 

Amit is a healthy man in his forties but his family history shows no sigh of Niemann pick disease type A . So Amit is not a carrier. Therefore, there is a 0% chance that the child will have Nieman-pick disease since it is an autosomal recessive allele. Amit will only provide the autosomal dominant allele in this gene; thus, the worst that will happen is the child will be a carrier if the mother is either affected or a carrier. Nieman-pick disease is inherited in an autosomal recessive pattern. It means both copies of the gene in each cell have mutations.Mutations in the NPC1, NPC2, AND SMPDI genes cause this disease

 

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