Van der Woude syndrome
Definition
Van der Woude syndrome (VWS) is a condition affecting the lips, palate, and teeth. Depressions or pits typically are present on the lower lip at birth and cleft lip and/or cleft palate may also be present. Less commonly, certain teeth may not develop. VWS has previously been known as the lip pit syndrome.
Description
Van der Woude syndrome primarily involves pits developing on the lower lip, clefting of the lip and/or palate, and the absence of certain teeth. More than 80% or more than 8 out of 10 individuals with VWS will develop pits near the center of the lower lip and about 60–70% (6 to 7 people out of 10) will have a cleft lip and/or palate at birth. About half to two-thirds of the individuals will have both lower lip pits and a cleft of the lip and/or palate. In some...
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