Sebastian syndrome
Definition
Sebastian syndrome is an extremely rare genetic disease that results in impaired blood clotting function and abnormal platelet formation. Another name for Sebastian syndrome is autosomal dominant macrothrombocytopenia with leukocyte inclusions.
Description
Sebastian syndrome is classified as one of the inherited giant platelet disorders (IGPDs). Platelet cells are components of the blood that play a key role in blood clotting. All IGPDs are associated with bleeding disorders due to improper platelet function and increased platelet cell size. Other IGPDs include May-Hegglin anomaly, Epstein syndrome, Fechtner syndrome, and Bernard-Soulier syndrome. Sebastian syndrome is distinguished from these other IGPDs by subtle differences in the platelet and white blood cell structure and by...
[The entire page is 1039 words long]
Join eNotes
Over 3,500 study guides, question and answer forums, literature criticism, reference content, and much more!
