Home > Encyclopedia of Genetic Disorders > Proteus syndrome

Definition

Proteus syndrome is characterized by excessive growth of cells. This can result in asymmetrical growth, benign (noncancerous) tumors, and pigmented skin lesions.

Description

Proteus syndrome is a rare condition. It was first described in 1979 by Michael Cohen. Hans-Rudolf Wiedemann named the condition after the Greek god Proteus, who could assume many forms. The disorder gained wide recognition when it became publicized that Joseph (John) Merrick, the person depicted in the movie The Elephant Man, probably had Proteus syndrome.

The excess growth of tissue that characterizes Proteus syndrome is progressive. It also tends to affect some tissues and not others. This can result in asymmetrical growth in the body, such as the skull, bones, spine, hands, feet, fingers, and...