Osler-Weber-Rendu syndrome
Definition
Osler-Weber-Rendu syndrome (OWR), or hereditary hemorrhagic telangiectasia (HHT), is a blood vessel disorder, typically involving recurrent nosebleeds and telangiectases (arteriovenous malformations that result in small red spots on the skin) of the lips, mouth, fingers, and nose. Arteriovenous malformations (AVMs) are abnormal, direct connections between the arteries and veins (blood vessels), causing improper blood flow. AVMs are often present in OWR, and may occur in the lungs, stomach, or brain.
Description
The story of OWR began years ago with a sequence of events between three prominent physicians, Osler, Weber, and Rendu. The earliest report of OWR was compiled by Rendu in 1896. Osler further characterized the condition in 1901, and F. Parkes Weber described many cases of...
[The entire page is 2596 words long]
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