Leigh syndrome
Definition
Leigh syndrome is a rare inherited neurometabolic disorder characterized by degeneration of the central nervous system (brain, spinal cord, and optic nerve), meaning that it gradually loses its ability to function properly.
Description
First described in 1951, Leigh syndrome usually occurs between the ages of three months and two years. The disorder worsens rapidly; the first signs may be loss of head control, poor sucking ability, and loss of previously acquired motor skills, meaning the control of particular groups of muscles. Loss of appetite, vomiting, seizures, irritability, and/or continuous crying may accompany these symptoms. As the disorder becomes worse, other symptoms such as heart problems, lack of muscle tone (hypotonia), and generalized weakness may develop, as well as...
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