Home > Encyclopedia of Genetic Disorders > Hand-foot-uterus syndrome

Definition

Hand-foot-uterus (HFU) syndrome is characterized by abnormalities of the hand, foot, urinary tract, and reproductive tract.

Description

HFU is a rare genetic condition. Its hallmarks include incurving of the fingers (clinodactyly) and shortened and relocated thumbs. There are also wrist- and ankle-bone fusions, very small feet, short great toes, urinary-tract abnormalities, duplications of the reproductive tract in women, urethral openings on the underside of the penis in men, and curved penis. HFU was first described in 1970. Based on the findings of genital abnormalities in affected males, a 1975 study suggested that the more accurate name of the syndrome would be hand-foot-genital (HFG) syndrome.

Genetic...