Familial adenomatous polyposis
Definition
Familial adenomatous polyposis is an inherited condition that typically presents with extensive adenomatous polyps of the colon. These polyps often develop into colorectal cancer in early adult life. Other symptoms are often present as well. These signs include polyps in the upper gastrointestinal tract, malignancies in the brain or thyroid, pigmented retinal lesions, and osteomas.
Description
Familial adenomatous polyposis (FAP) was first clearly described as a dominantly inherited colorectal cancer susceptibility by Lockhart-Mummery in an article published in 1925. FAP has since served as a paradigm for hereditary cancer and has taught much about the diagnosis, surveillance, and management of...
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