Coffin-Lowry syndrome
Definition
Coffin-Lowry syndrome (CLS) is an inherited syndrome characterized by mental retardation, slow growth, distinctive facial appearance, large soft hands, loose joints, minor skeletal changes, and low muscle tone (hypotonia). Full expression of the disorder is seen only in males, although females may have some of the physical features and learning disability.
Description
Coffin-Lowry syndrome is one of a large number of mental retardation syndromes caused by abnormalities (mutations) of genes on the X chromosome. The pattern of physical findings, combined with mental retardation, makes the condition readily recognizable and its frequency makes it one of the well-known X-linked mental retardation syndromes. Although CLS was initially considered to be two separate syndromes, Coffin...
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