Androgen insensitivity syndrome
Definition
Androgen insensitivity syndrome is a genetic condition where affected people have male chromosomes and male gonads (testicles). The external genitals, however, have mild to complete feminization.
Description
Normal sexual development
In normal development, the chromosome sex determines the gonadal sex, which in turns determines the phenotypic sex. The chromosome sex is determined at conception; a male has the sex chromosome pair XY and a female has the chromosome pair XX. During the first 40 days of gestation, a male and female embryo appear the same and have undifferentiated gonads, which have the potential of becoming testes or ovaries....
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