Dec 28, 2009
Alkaptonuria is a rare, inherited disorder characterized by urine that turns dark when exposed to air, dark pigmentation of the cartilage and other tissues, and arthritis.
Alkaptonuria (AKU) (sometimes spelled alcaptonuria) is a disorder in which a substance called homogentisic acid (HGA) accumulates in cells and connective tissues throughout the body. Large amounts of HGA also are excreted in the urine. In a process known as ochronosis, deposits of HGA form dark pigments in the skin, joints, and other tissues of the body. Over the long term, ochronosis leads to ochronotic arthritis, which is a painful inflammation and stiffening of the joints. AKU is also known as homogentisic acid oxidase deficiency, ochronosis, alkaptonuria ochronosis, or ochronotic arthritis.
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