Hydromorphone - Reactions with Other Drugs or Substances

Reactions with Other Drugs or Substances

Since it is a powerful central nervous system depressant, hydromorphone will enhance the effects of other drugs and alcohol. Drinking alcohol while taking hydromorphone will increase the likelihood of breathing problems and loss of muscle control. The

Addiction to narcotics is extremely difficult to overcome. Abusers of powerful opiates often need to be hospitalized in a rehabilitation clinic. Photograph by Leitha Etheridge-Sims.
Addiction to narcotics is extremely difficult to overcome. Abusers of powerful opiates often need to be hospitalized in a rehabilitation clinic. Photograph by Leitha Etheridge-Sims.

drug also should not be combined with antihistaminesDrugs that block histamine, a chemical that causes nasal congestion related to allergies. such as Benadryl; drugs for nervous disorders such as Nembutol, Restoril, Thorazine, Valium, or Xanax; or antidepressants such as Elavil and Tofranil. Persons taking other opiate painkillers such as Vicodin, Demerol, Percocet, or fentanyl should not use hydromorphone.

Because it reacts so strongly with other drugs—and because it is a powerful painkiller with potentially dangerous side effects—hydromorphone is not prescribed to be taken on an "as needed" basis. People receiving valid, legal prescriptions for hydromorphone need to take it on a daily schedule, sometimes for a prolonged period of time. Patients receiving hydromorphone need to tell their doctors about any other medications they are taking. The medicine must be kept out of reach of children. Palladone was not prescribed for anyone under eighteen.

After taking hydromorphone for a period of weeks, patients will need to gradually lower the dosage slowly to avoid withdrawal symptoms. This is done under a doctor's supervision.