Diuretics - Reactions with Other Drugs or Substances

Reactions with Other Drugs or Substances

Over-the-counter diuretic preparations are available in any drug store. Even though some diuretics are available without a prescription, the risk for serious side effects remains. Diuretics should always be taken under the recommendation and guidance of a trained healthcare professional.

Diuretics affect potassium levels. Drugs that are known to decrease potassium levels (certain anti-inflammatory steroids and heart drugs, for instance) should be avoided by anyone taking potassium-depleting diuretics. Potassium deficiencies can cause potentially dangerous side effects. In contrast, patients taking potassium-sparing diuretics such as amiloride, spironolactone, or triamterene should not eat foods high in potassium. The action of these diuretics raises the amount of potassium in their bodies. Thus, food rich in potassium—bananas, tomatoes, sweet potatoes, and oranges, to name a few—would only add to the problem and should be avoided.

Individuals taking prescription diuretics should always check with their doctors before adding herbal supplements

St. Johns wort, available as an herbal remedy, acts as a natural diuretic.  Clay Perry/Corbis.
St. John's wort, available as an herbal remedy, acts as a natural diuretic. © Clay Perry/Corbis.

to their drug regimen. Herbal diuretics can actually increase the effect of prescription diuretics, so the two should not be combined. Some of the more well-known diuretic herbs include bilberry, celery seed, dandelion leaf, goldenrod, horse chestnut seeds, juniper, parsley, and St. John's wort. Foods and beverages rich in caffeine—such as chocolate, coffee, and tea—can also have a diuretic effect at high doses. They should not be consumed in excess with prescription diuretics. Alcohol has a diuretic effect as well and should be avoided by patients taking doctor-prescribed diuretics.