Dextromethorphan - Reactions with Other Drugs or Substances

Reactions with Other Drugs or Substances

As previously stated, over-the-counter multi-symptom cold and cough products contain several ingredients that can be poisonous at high doses. The dextromethorphan abuser may unknowingly risk fatal organ damage by taking too much acetaminophen. Breathing problems can occur if too much decongestantA drug that relieves nasal congestion. is consumed with DXM. Combining dextromethorphan with prescription drugs, controlled substances, or alcohol can prove fatal.

Even at normal doses, dextromethorphan can react negatively with prescription sedatives, antidepressant drugs known as MAO inhibitors, and the antidepressant family of drugs that includes Desyrel (trazadone) or Serzone (nefazodone). Any amount of dextromethorphan combined with a selective serotonin reuptake inhibitor (SSRI), such as Prozac, Paxil, or Zoloft, can cause chemical imbalances in the brain. Dextromethorphan is also to be avoided by anyone taking tricyclic antidepressants or medication for bipolar disorderA psychological disorder that causes alternating periods of depression and extreme elevation of mood., such as lithium carbonate or Depacote. (A separate entry on antidepressants is available in this encyclopedia.)

Occasionally, drug dealers will pass dextromethorphan pills or powders off as ketamine, ecstasy (MDMA), or even heroin. (An entry on each of these drugs is available in this encyclopedia.) Unsuspecting users can suddenly find themselves with a whole series of symptoms for which they are not prepared. In the New York Times, Jacob Sullum reported that this substitution of dextromethorphan for other illicit drugs has led some dance clubs to test pills and powders on-site in order to protect customers from unknowingly taking overdoses of the dangerous DXM.

The combination of dextromethorphan products and alcohol can cause extreme nausea and vomiting, as well as a greater loss of motor control.