Codeine - Reactions with Other Drugs or Substances

Reactions with Other Drugs or Substances

Pharmacists dispensing drugs containing codeine usually warn users that side effects can include drowsiness, dizziness, nausea, and constipation. These substances should not be used with other tranquilizers or sedativesA drug used to treat anxiety and calm people down., with benzodiazepinesA type of drug used to treat anxiety., with the antidepressant drugs known as monoamine oxidase inhibitors (MAOIs), or with antihistaminesDrugs that block histamine, a chemical that causes nasal congestion related to allergies. , amphetaminesPronounced am-FETT-uh-meens; stimulant drugs that increase mental alertness, reduce appetite, and help keep users awake., or alcohol. Patients taking products that contain codeine must use care when operating automobiles or machinery. When used briefly and specifically for its prescribed purpose, a product containing codeine will not produce extreme side effects.

Doctors prescribing pain relievers containing codeine must carefully check the patient's records for other medications that will adversely interact with codeine. These substances include sleeping pills, tranquilizers, antihistamines, anti-anxiety medications, and any other medicine that produces sedation. Using alcohol and codeine at the same time greatly increases the likelihood of breathing problems. Mixing codeine with illegal substances such as hallucinogensA substance that brings on hallucinations, which alter the user's perception of reality. or designer drugs can be fatal.

Additionally, higher doses of prescription pain relief pills containing codeine and/or acetaminophen, ibuprofen, and aspirin can cause severe, sometimes fatal, reactions. Over-the-counter analgesics taken in large doses can lead to stomach bleeding, liver failure, and other organ damage.