Methotrexate
Definition
Methotrexate is a folic acid derivative that interferes with folic acid metabolism (folate antagonist). It is a cytotoxic agent (a chemical that is directly toxic to cells) with multiple characteristics and may be described as an antimetabolite, antineoplastic, and immunosuppressant. In the United States, methotrexate is also recognized by the trade names Folex and Mexate, or the generic name amethopterin.
Purpose
Methotrexate is administered to cancer patients diagnosed with various malignancies. These conditions may include breast cancer, lung cancer, non-metastatic bone cancer, cancers associated with the head and neck,
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