Home > Encyclopedia of Cancer > Matrix Metalloproteinase Inhibitors

Definition

Matrix metalloproteinases are a class of enzymes that can break down proteins, such as collagen and gelatin. Since these enzymes require zinc or calcium atoms to function, they are referred to as metalloproteinases. Matrix metalloproteinases function in tumor cell invasion and metastasis, wound healing, and angiogenesis. They are normally found in the spaces between cells (extracellular) in tissues and are involved in degrading extracellular matrix proteins like collagens and gelatins. The extra-cellular matrix compartments are the primary barriers to tumor growth and spread. Matrix metalloproteinase inhibitors are selective inhibitors of matrix metalloproteinases. These agents inhibit tumor metastasis and angio-genesis (supplying the tumor with blood).