Gemtuzumab
Definition
Gemtuzumab ozogamicin is a humanized monoclonal antibody produced by recombinant DNA technology that binds specifically to CD33, a protein that is found on the cell surface of most leukemic blasts, the abnormal, cancerous cells in acute myeloid leukemia (also known as acute myelocytic leukemia, or AML). It is marketed in the United States under the brand name Mylotarg.
Purpose
Gemtuzumab is a monoclonal antibody used to treat AML that is characterized by expression of the CD33 protein on the cancerous cells, called leukemic blasts. The CD33 protein is found on the surface of the leukemic blasts of about 80% of AML patients. After the gemtuzumab antibody is produced in the laboratory,...
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