Home > Encyclopedia of Cancer > Dacarbazine

Definition

Dacarbazine, also known as DTIC-Dome or DTIC, is an anticancer agent best known for its long-time use in treating metastatic malignant melanoma.

Purpose

Dacarbazine has been approved by the Federal Drug Administration (FDA) for use in the treatment of metastatic malignant melanoma and Hodgkin's lymphoma, as well as other neoplasms.

Metastatic malignant melanoma

Dacarbazine used alone produces a response in up to 25% of patients with metastasis to the surrounding skin and lymph nodes. Though it has been studied in combination with other drugs, and some...